团队负责人

孙秀兰

团队成员

纪剑、孙嘉笛、盛利娜、叶永丽、高松

团队简介

食品安全感知科学与减损技术研究团队长期致力于食品加工中微生物毒素等污染物的监测、风险评价与健康干预研究。聚焦毒素毒性效应变化、特异性生物蛋白、代谢标志物等，开展了从产毒菌源头到已知生物毒素的主动控制与暴露干预的技术体系。先后主持承担了国家杰出青年基金、国家重点研发计划、国家863、973计划等科研项目30余项。在权威杂志发表论文300余篇，获中国发明专利40件、国际发明专利4件，参与制订国家行业标准9项，国际标准2。相关成果获省部级及行业协会（江苏省、教育部、中国轻工业联合会）技术发明、科技进步一等奖5项

代表性成果

1.科研项目

[1]国家杰出青年科学基金，食品加工中生物毒素控制，2022.01-2026.12，国家级

[2]科技部“十三五”重点研发计划项目，适配体和核糖开关的精准设计与高效合成，2021.12-2026.11，国家级

[3]云南省科技计划项目-重大科技专项计划，核桃抗氧化劣变调控及特征风味保持关键技术研发，2022.09-2025.08，省级

[4]江苏省农业科技自主创新资金计划,农产品流通过程典型危害物荧光编码传感及可视化智能监控系统研究与应用, 2022.09-2024.08，省级

[5]科技部“十三五”重点研发计划项目，食品多组分物性劣变信号分子快速识别与传感技术研发，2016.07-2021.06，国家级

[6]国家粮食局行业科研专项，主要真菌毒素、重金属污染粮油的安全合理利用技术研究，2015.01-2017.12，国家级

[7]国家自然科学基金面上基金，基于信号靶点识别的敏感细胞传感检测呕吐毒素及其降解产物毒性评价体系的建构研究，2018.01-2021.12，国家级

[8]国家自然科学基金面上基金，基于敏感细胞识别的食源性致病菌毒力分析模型研究，2014.01-2017.12，国家级

[9]国家自然科学基金-广东省人民政府联合基金，藻毒素多目标广谱特异性免疫分析分子识别基础，2014.01-2017.12，国家级

[10]云南省科技计划项目-重大科技专项计划，核桃功能性系列产品开发及产业化应用，2018.01-2020.12，省级

[11]江苏省农业科技自主创新资金计划，可视化检测除草剂残留的新型荧光纳米传感技术的构建及产品研发，2017.06-2020.05，省级

2.发明专利

[1]Sun.X.L,Sun.J.D,Ji.J,Zhang.Y.Z,Wei.K.M. Cell Electrochemical Sensor Based on 3D Printing Technology and Application Thereof. US11,279,079 B2

[2]Sun.X.L,Xu.Y.D,Xu.D.P,Zhang.Y.Z. Method For separating phenolic acid glucside compounds from Diaphragma Juglandis Fructu. US11,384,109 B2

[3]Sun.X.L,Ye.Y.L,Hong.Q.Q,Xu.D.P,Zhang.Y.Z,Geng.S.X. 1-Carboxy-2Hydroxy-3-Iminopropane And Extraction Method Thereof. US11,655,208 B2

[4]Sun.X.L,Zhang.Y.Z,Li.Z.J,Zhang.J.P,Niu.W.M. An Antibody Protective Agent and Methods of Using Same.US 8，12，700 B2

[5]孙秀兰，邹东，纪剑，孙嘉笛，叶永丽，张银志。一种黑曲霉菌株及其在赭曲霉毒素A降解中的应用。ZL2021110806739.

[6]孙秀兰，杨嘉，纪剑，付旭冉，孙嘉笛，叶永丽，张银志。一种基于纸芯片快速提取超纯DNA的方法。ZL2021108781644.

[7]孙秀兰，纪剑，于坚，孙嘉笛，张银志。一株可快速同时降解三种真菌毒素的黑曲霉及其应用。ZL2021106772316.

[8]孙秀兰，王良哲，孙嘉笛，叶永丽，纪剑，张银志。一种同时提取谷物中镉、黄曲霉毒素B1和乐果的方法。ZL2021104886242.

[9]孙秀兰，徐洪文，孙嘉笛，纪剑，张银志，叶永丽。一种基于PDA@Fe3O4-MWCNTs检测食用植物油中多种真菌毒素的方法。ZL2021100959776.

[10]孙秀兰，高璐，纪剑，张银志，孙嘉笛，叶永丽。一种用于检测雄激素的装置。ZL2021216018392.

[11]孙秀兰，韦凯敏，孙嘉笛，纪剑，张银志。一种基于3D打印技术的细胞电化学传感器及其应用。ZL202010249330X.

[12]孙秀兰，任奕婧，纪剑，孙嘉笛，皮付伟，张银志。一种细菌耐药性电化学检测方法。ZL201910794286.8.

[13]孙秀兰，纪剑，黄鹤阳，任奕婧，皮付伟。一种便携式AHL分子印迹丝网印刷电化学检测仪。ZL2019103174262.

[14]孙秀兰，杨星星，郑佳玉，纪剑，范明红，李红梅，杨抗震，韩华。一种橙色荧光碳点及其制备方法。ZL201811406451X.

[15]孙秀兰，纪剑，皮付伟，张银志，郭巍，单雪晴。一种用于脱除展青霉素的纳米材料的合成与应用。ZL2018108239023.

[16]孙秀兰，单雪晴，纪剑，皮付伟，张银志，杨惠成。一种百草枯分子印迹电极、制备及应用。ZL2018105164311.

[17]鲍琦，孙秀兰，汤璐瑶，孙嘉笛，张银志，纪剑，叶永丽。一种用于食品安全检测装置。ZL2022209221090.

[18]纪剑，于坚，孙秀兰*，张银志，孙嘉笛，邹东，杨阳。一株可快速降解玉米赤霉烯酮的黑曲霉及其应用。ZL2020114924744.

[19]鲍琦，孙秀兰*，汤璐瑶，孙嘉笛，张银志，纪剑，叶永丽。一种病菌检测装置。ZL2022209196811.

3.科研获奖

[1]粮油加工中真菌毒素防控及生物减损技术创新与应用，中国轻工业联合会，科技进步一等奖，2023

[2]食品加工中生物毒素控制创新技术与应用,江苏省人民政府,科学技术一等奖,2019

[3]粮油精深加工过程中生物毒素的检测与防控技术创新与应用,中国轻工业联合会,科技进步一等奖,2020

[4]粮油加工中生物毒素防控创新关键技术及应用，中国商业联合会，科技进步特等奖，2020

[5]食品中化学污染物精准免疫识别及快速检测技术，教育部高等学校科学研究优秀成果奖，一等奖，2020

[6]多功能水槽式清洗机关键技术研发及产业化，浙江省科学技术进步二等奖，2020，

[7]食品安全关键检测技术研究与应用，江苏省科学技术三等奖，2013

[8]食品中危害因子快速识别与控制关键技术研究与应用，中国轻工业联合会科技进步三等奖,2013

[9]高灵敏食品安全生物检测技术的研究与推广应用，中国商业联合会科技进步一等奖，2013

4.学术论文

[1]Qi Bao1;Jiadi Sun1; Xuran Fu; Lina Sheng; Yongli Ye; Jian Ji; Yinzhi Zhang; Jiasheng Wang; Jianping Feng; Xiulan Sun*. A Simplified Amplification‐Free Strategy with Lyophilized CRISPR‐CcrRNA System for Drug‐Resistant Salmonella Detection. Small, 2023, 19(29): 2207343.

[2]Xuran Fu;Jiadi Sun*;BingqianYu; Yongli Ye; Lina Sheng; Jian Ji; Jiayu Zheng; Minghong Fan; Jingdong Shao; Xiulan Sun*. Investigating enzyme kinetics and fluorescence sensing strategy of CRISPR/Cas12a for foodborne pathogenic bacteria[J]. Analytica Chimica Acta, 2024, 1290: 342203.

[3]Yongli Ye1, Jiadi Sun1, Jiayuan Xu1, Peipei Li, Lina Sheng, Yuan Qian，Jian Ji, Xiaomin Han, Xinrui Zhao, Jingwen Zhou, Xiulan Sun * Allergenic risk assessment of porcine myoglobin expressed by engineered Komagataella Phaffii[J]. Fundamental Research, 2024.

[4]Bingqian Yu1, Qirui Liu1,Jiadi Sun*, Xuran Fu, Yinzhi Zhang, Xiulan Sun*. Phototherapy-based multifunctional nanoplatform for synergistic therapy against drug resistance bacteria: Progress, advances and challenges. Chemical Engineering Journal, 2024: 150705.

[5]Ziyue Wang 1, Lina Sheng 1, Xingxing Yang, Jiadi Sun, Yongli Ye, Shuxiang Geng, Delu Ning, Jiayu Zheng, Minghong Fan, Yinzhi Zhang, Xiulan Sun*. Natural biomass-derived carbon dots as potent antimicrobial agents against multidrug-resistant bacteria and their biofilms[J]. Sustainable Materials and Technologies, 2023, 36: e00584.

[6]Xuran Fu1;Jiadi Sun1; Yongli Ye; Yinzhi Zhang; Xiulan Sun*.A rapid and ultrasensitive dual detection platform based on Cas12a for simultaneous detection of virulence and resistance genes of drug-resistantSalmonella. Biosensors and Bioelectronics, 2022, 195: 113682.

[7]Xuran Fu, Jiadi Sun, Rong Liang, Hongyan Guo, Liping Wang,Xiulan Sun*. Application progress of microfluidics-integrated biosensing platforms in the detection of foodborne pathogens, Trends in Food Science & Technology, 2021, 116, 115-129

[8]Lina Sheng, Luxin Wang*. Approaches for a more microbiologically and chemically safe dried fruit supply chain[J]. Current opinion in biotechnology, 2023, 80: 102912.

[9]Lina Sheng, Xinran Li, Luxin Wang* Photodynamic inactivation in food systems: A review of its application, mechanisms, and future perspective[J]. Trends in Food Science & Technology, 2022, 124: 167-181.

[10]Lina Sheng, Meijun Zhu* Practical in-storage interventions to control foodborne pathogens on fresh produce.Comprehensive Reviews in Food Science and Food Safety.2021, 20: 4584-4611.

[11]Yongli Ye, Jian Ji, Zhanyi Sun, Peili Shen, Xiulan Sun*.Recent advances in electrochemical biosensors for antioxidant analysis in foodstuff, TrAC Trends in Analytical Chemistry, 2019, 122: 115718-115729.

[12]Xin Lu, Jiadi Sun,Xiulan Sun*.Recent advances in biosensors for the detection of estrogens in the environment and food, TrAC Trends in Analytical Chemistry, 2020, 127: 115882-115890

[13]Fangchao Cui , Jiadi Sun, Jian Ji, Xingxing Yang, Kaimin Wei, Hongwen Xu, Qingyin Gu, Yinzhi Zhang,Xiulan Sun*. Carbon dots-releasing hydrogels with antibacterial activity, high biocompatibility, and fluorescence performance as candidate materials for wound healing, Journal of Hazardous Materials, 2021, 406: 124330.

[14]Jiadi Sun, Fuwei Pi, Jian Ji, Hongtao Lei, Zhixian Gao, Yinzhi Zhang, Habimana Dieu Jean de, Zaijun Li,Xiulan Sun*. Ultrasensitive“FRET-SEF”Probe for Sensing and Imaging MicroRNAs in living cells based on gold nanoconjugates, Analytical Chemistry, 2018.1.8, 90(5): 3099~3108

[15]Jiadi Sun, Fangchao Cui, Ruyuan Zhang, Zhixian Gao, Jian Ji, Yijing Ren, Fuwei Pi, Yinzhi Zhang,Xiulan Sun*. Comet-like Heterodimers“Gold Nanoflower@ Graphene Quantum Dots”Probe with FRET“Off”to DNA Circuit Signal“On”for sensing and imaging microrna in vitro and in vivo, Analytical chemistry, 2018.9.5, 90(19): 11538~11547