团队负责人

陆乃彦

团队成员

唐雪、成向荣、朱建津

团队简介

团队在膳食营养基础与应用、食药同源天然产物对运动机能、衰老及损伤的改善与调控作用进行了大量研究。主持了包括国家自然科学基金、科技支撑计划、国家重点研发子课题、江苏省自然科学基金、江苏省农业自主支撑计划、在内的科研项目30多项，发表200余篇学术论文，获得20项发明专利和省部级科研奖项。长期与小仙炖、东阿阿胶、佳格、达能、松下、华帝等知名企业开展产学研项目合作。

代表性成果

1.科研项目

[1]2019,国家自然科学基金面上项目,高密度接枝对乳酸链球菌素抗菌效果的增强及其机理

[2]2019，国家自然科学青年基金，食源性双酪氨酸介导组织氧化损伤的分子机制及营养干预研究

[3]2018，国家自然科学青年基金，小黑药中迈克尔反应受体分子的发现及其降脂毒性作用研究

[4]2017,国家重点研发计划子课题,基于我国母乳组分的特需乳制品创制及共性关键技术研究

2.发明专利

[1]2024, 202410696216.X,一种防治急性肝损伤的缩醛磷脂及其制备方法,发明专利

[2]2024, 202410696218.9,一种预防和修复肾损伤的缩醛磷脂及其制备方法,发明专利

[3]2024, 202410696222.5,一种预防或/和治疗肺纤维化和急性肺损伤的缩醛磷脂及其制备方法,发明专利

[4]2024, 202410616743.5,转染TG2基因促进EMSCs治疗急性肝衰竭,发明专利

[5]2023, 202310686165.8,牛蒡多糖在间充质干细胞中的应用,发明专利

[6]2023，202110143314.7，一种高谷氨酸驴胶原活性肽的应用，发明专利

[7]2022，201910992278.4，百里香酚异丁酸酯在制备降血脂药物中的应用，发明专利

[8]2021，201910992146.1，小黑药提取物在制备降血脂药物中的应用，发明专利

3.科研获奖

[1]2021年，中国商业联合会科技进步奖一等奖，天然抗菌抗应激功能成分筛选与制备关键技术及应用，省部级

[2]2022年，中国商业联合会科技进步奖特等奖，药食同源植物功能成分提取精制关键技术研发与产业化应用，省部级

4.学术论文

[1]Xue Mei, Wen Xiang, Wenyan Pan, Quan Lin, Xueyan Jia, Xuan Zhang, Xue Tang, Xiangrong Cheng, Yuyan Weng, Kai Yang, Naiyan Lu. Plasmalogens Reversed Oxidative Stress and Inflammatory Response Exacerbated by Damage to Cell Membrane Properties in Acute Liver Injury. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024.

[2]Haotian Zhao, Hongkang Zhu, Hezhang Yun, Jingqi, Liu, Ge Song, Jin Teng, Dixin Zou, Naiyan Lu, Chang Liu. Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study. JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, 2024, 24(1): 2419388.

[3]Xueyan Jia, Haoming Liu, Guoliang Yin, Wen Xiang, Haotian Zhao, Xuan Zhang, Xue Tang, Xiangrong Cheng, Chia-Feng Kuo, Chang Liu, Wei Wang, Naiyan Lu. Arctium lappa L. polysaccharides alleviate oxidative stress and inflammation in the liver and kidney of aging mice by regulating intestinal homeostasis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024, 280(2): 135802.1.Xue Tang, Yingying Zheng, Tristan C. Liu, Jianguo Liu, Jun Wang, Yipin Lu, Kai Zhang, Peng Zhou. Fragrant rapeseed oil consumption prevents blood cholesterol accumulation via promoting fecal bile excretion and reducing oxidative stress in high cholesterol diet fed rats. Journal of Functional Foods.2022 (88): 104893

[4]Jun Wang, Xue Tang#, Yipin Lu, Yingying Zheng, Fanhang Zeng, Wentao Shi , Peng Zhou. Lycopene Regulates Dietary Dityrosine-Induced Mitochondrial-Lipid Homeostasis by Increasing Mitochondrial Complex Activity. Molecular Nutrition & Food Research, 2022, 66(1):e2100724.

[5]Yipin Lu, Shuhua Ma, Xue Tang#, Bowen Li, Yueting Ge, Kai Zhang, Shaojun Yang, Qi Zhao, Ying Xu, Haoyi Ren. Dietary Dityrosine Induces Mitochondrial Dysfunction by Diminished Thyroid Hormone Function in Mouse Myocardia. Journal of Agricultural and Food Chemistry, 2020, 68(34):9223-9234.

[6]Xue Tang, Shuhua Ma, Yingrui Li, Yongjuan Sun , Kai Zhang , Qin Zhou, Renqiang Yu.Evaluating the Activity of Sodium Butyrate to Prevent Osteoporosis in Rats by Promoting Osteal GSK-3β/Nrf2 Signaling and Mitochondrial Function. Journal of Agricultural and Food Chemistry,2020, 68(24):6588-6603.

[7]Wen Xiang, Guoliang Yin, Haoming Liu, Jiayi Wei, Xinghui Yu, Yan Xie, Li Zhang, Xue Tang, Wentao Jiang, Naiyan Lu. Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024, 261:129670.

[8]Wentao Shi, Yunduan Que, Xuan Zhang, Lu Bian, Xuejian Yu, Xue Tang, Guofeng Yang, Yao Dai, Shiqi Bi, Demin Lv, Yuyan Weng, Weijiang Wu, Zhijian Zhang, Xiaojie Lu, Naiyan Lu. Functional tissue-engineered bone-like graft made of a fibrin scaffold and TG2 gene-modified EMSCs for bone defect repair. NPG-ASIA MATERIALS. 2021, 13(1): 28.

[9]Cheng, X.-R.; Ma, J.-H.; Amadou, I.; Zhao, W.; Chen, Y.-Y.; Zhang, C.-X.; Guan, B. Electrophilic components from Xiaoheiyao (rhizomes of Inula nervosa Wall.) alleviate the production of heterocyclic aromatic amines via creatinine inhibition. Food Chemistry 2023, 404, 134561.

[10]Weng, J.-Y.; Yang, J.-Y.; Papy, I. S.; Yu, B.-T.; Ke, Y.-F.; Bai, B.-Y.; Muskat, M. N.; Wu, Q.; Cheng, X.-R. Cinnamaldehyde alleviates hepatic steatosis correlating with its electrophilic capability. Food Bioscience 2024, 59, 104142.

[11]Cheng, X.-R.; Chen, Y.-Y.; Cao, C.-C.; Ma, J.-H.; Zhang, C.-X.; Zhao, Z.-W.; Wu, Q.; Li, Y.-Y.; Muskat, M. N.; Wu, G.-Q. Ejiao peptide-iron chelates regulate the metabolism of iron deficiency anemia mice and improve the bioavailability of iron. Food Bioscience 2023, 54, 102835.